Two Melanin-concentrating hormone receptors (MCHR) have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology.

  • MCH-R1 is expressed in all mammals.
  • MCH-R2 is only found in some primates and carnivores including dogs, ferrets and humans.

Clinical significance

Antagonists might be useful in the treatment of obesity and anxiety and depression. An agonist might have possible utility as a treatment for osteoporosis and insomnia

Research is ongoing for antagonists affecting MCH receptors R1 and R2.

See also

  • Melanin concentrating hormone
  • Melanin

References

External links

  • "Melanin-Concentrating Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
  • melanin-concentrating hormone receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • MCHR1 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • MCHR2 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)



MelaninConcentrating Hormone (Human) Molecular Depot

(PDF) The Melaninconcentrating Hormone System in Human, Rodent and

Tyrosine To Melanin Pathway

(PDF) Preclinical Evaluation of MelaninConcentrating Hormone Receptor

Signalling pathways of melaninconcentrating hormone receptor 1 (MCHR1